Cyber Resilience

CVE-2025-12921

Openclinica 3.12.2 … 3.13

Public PoC
Published
10 November 2025
Modified
29 April 2026
CVSS Score v4 2.1
Click a component to see what it means
Raw vectorCVSS:4.0/AV:N/AC:L/AT:N/PR:L/UI:N/VC:L/VI:N/VA:N/SC:N/SI:N/SA:N/E:P/CR:X/IR:X/AR:X/MAV:X/MAC:X/MAT:X/MPR:X/MUI:X/MVC:X/MVI:X/MVA:X/MSC:X/MSI:X/MSA:X/S:X/AU:X/R:X/V:X/RE:X/U:X
EPSS Score 0.0053 42th percentile
Risk Priority 28 floored blend · peak EPSS

CVSS and EPSS are reproduced from their sources (NVD, FIRST EPSS). Risk Priority is our own derived reading, not an NVD score.

Summary

CVE-2025-12921 is a low-severity Injection (CWE-74) vulnerability in Openclinica Openclinica. Its CVSS base score is 2.1 (Low).

Operationally, exploitation aligns with the MITRE ATT&CK technique Exploit Public-Facing Application (T1190); ranked at the 42th percentile by exploit likelihood (below the median); it is not currently listed in the CISA KEV catalog; a public proof-of-concept is referenced.

The strongest mitigations our analysis identified map to SI-10 (Information Input Validation) — see the control section below for these in your framework.

OWASP Top 10 for Web (2025)

A05:2025 Injection

EU & UK References

Vulnerability Data

A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection.…

more

It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.

CWE(s)
CWE-74CWE-91

Related Threats

MITRE ATT&CK Enterprise Techniques

T1190 Exploit Public-Facing Application Initial Access
Adversaries may attempt to exploit a weakness in an Internet-facing host or system to initially access a network.
attack.mitre.org →
T1221 Template Injection Stealth
Adversaries may create or modify references in user document templates to conceal malicious code or force authentication attempts.
attack.mitre.org →
T1659 Content Injection Initial Access
Adversaries may gain access and continuously communicate with victims by injecting malicious content into systems through online network traffic.
attack.mitre.org →
T1674 Input Injection Execution
Adversaries may simulate keystrokes on a victim’s computer by various means to perform any type of action on behalf of the user, such as launching the command interpreter using keyboard shortcuts, typing an inline script to be executed,…
attack.mitre.org →
T1059 Command and Scripting Interpreter Execution
Adversaries may abuse command and script interpreters to execute commands, scripts, or binaries.
attack.mitre.org →
T1059.001 PowerShell Execution
Adversaries may abuse PowerShell commands and scripts for execution.
attack.mitre.org →
Derived from this CVE’s CWE(s) via the direct CWE→ATT&CK cross-walk.

CVEs Like This One

CVE-2024-13190Shared CWE-74, CWE-91
CVE-2023-27040Shared CWE-74
CVE-2023-49964Shared CWE-74
CVE-2026-6279Shared CWE-74
CVE-2025-27794Shared CWE-74
CVE-2023-48205Shared CWE-74
CVE-2025-40710Shared CWE-74
CVE-2023-43655Shared CWE-74
CVE-2023-29827Shared CWE-74
CVE-2023-29526Shared CWE-74

Affected Assets

openclinica
openclinica
3.12.2, 3.13

Mitigating Controls

Control response

Prevent
Stop it (NIST 800-53)

—

Detect
Catch it (NIST detect / respond)

—

Harden
Shrink the surface (DISA STIG)

—

Validate
Prove the fix (OWASP ASVS)
  • V1.2.1
  • V1.2.3
  • V1.2.5
  • V1.2.8

Mitigating Controls (NIST 800-53 r5) AI

SI-10 Information Input Validation good match

SI-10 directly requires validation of information inputs to reject malformed or special-element content before it reaches downstream parsers.

Mitigating Controls (NIST CSF 2.0) AI

Derived directly from the weakness types (CWEs) cited in the NVD entry via our AI-authored CWE→CSF cross-walk (authority under review) — links open the control.

PR.PS-06 mostly match
prevents

Secure SDLC practices directly require input validation and output encoding that prevent injection flaws.

Mitigating Controls (ISO/IEC 27001:2022 Annex A) AI

Derived directly from the weakness types (CWEs) cited in the NVD entry via our AI-authored CWE→ISO cross-walk (authority under review) — links open the control.

A.8.29 Security testing in development and acceptance mostly match
finds

Security testing in development catches injection vulnerabilities before release.

A.8.15 Logging partial match
finds

Logging supports detection of injection attempts but does not prevent the weakness.

A.8.16 Monitoring activities partial match
finds

Monitoring activities can identify active injection attacks after they occur.

A.8.25 Secure development life cycle partial match
prevents

Secure development life cycle mandates input validation and output encoding that directly prevent injection flaws.

A.8.26 Application security requirements partial match
prevents

Application security requirements explicitly call for controls against injection attacks in software design.

A.8.27 Secure system architecture and engineering principles partial match
prevents

Secure architecture principles reduce injection surfaces but do not prescribe specific neutralization techniques.

References