Cyber Resilience

CVE-2025-12921

LowPublic PoC

Published: 10 November 2025

Published
10 November 2025
Modified
29 April 2026
KEV Added
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Patch
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CVSS Score v4 2.1 CVSS:4.0/AV:N/AC:L/AT:N/PR:L/UI:N/VC:L/VI:N/VA:N/SC:N/SI:N/SA:N/E:P/CR:X/IR:X/AR:X/MAV:X/MAC:X/MAT:X/MPR:X/MUI:X/MVC:X/MVI:X/MVA:X/MSC:X/MSI:X/MSA:X/S:X/AU:X/R:X/V:X/RE:X/U:X
EPSS Score 0.0004 12.7th percentile
Risk Priority 4 60% EPSS · 20% KEV · 20% CVSS

Summary

CVE-2025-12921 is a low-severity Injection (CWE-74) vulnerability in Openclinica Openclinica. Its CVSS base score is 2.1 (Low).

Operationally, exploitation aligns with the MITRE ATT&CK technique Data from Local System (T1005); ranked at the 12.7th percentile by exploit likelihood (below the median); it is not currently listed in the CISA KEV catalog; a public proof-of-concept is referenced.

EU & UK References

Vulnerability details

A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection.…

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It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.

CWE(s)
CWE-74CWE-91

Related Threats

MITRE ATT&CK Enterprise TechniquesAI

T1005 Data from Local System Collection
Adversaries may search local system sources, such as file systems, configuration files, local databases, virtual machine files, or process memory, to find files of interest and sensitive data prior to Exfiltration.
attack.mitre.org →
T1083 File and Directory Discovery Discovery
Adversaries may enumerate files and directories or may search in specific locations of a host or network share for certain information within a file system.
attack.mitre.org →
T1190 Exploit Public-Facing Application Initial Access
Adversaries may attempt to exploit a weakness in an Internet-facing host or system to initially access a network.
attack.mitre.org →
T1505 Server Software Component Persistence
Adversaries may abuse legitimate extensible development features of servers to establish persistent access to systems.
attack.mitre.org →
Why these techniques?

XML injection (XXE) in OpenClinica web app enables remote exploitation of public-facing application (T1190), server software component abuse (T1505), and local file disclosure/discovery (T1005, T1083).

Affected Assets

openclinica
openclinica
3.12.2, 3.13

Mitigating Controls

Likely Mitigating Controls AI

Per-CVE control mapping for this CVE has not run yet; the list below is derived from the weakness types (CWEs) cited in the NVD entry.

SA-11 Developer Testing and Evaluation
addresses: CWE-74

Developer assessments and testing (including injection-focused techniques) identify improper neutralization of special elements, and the verifiable flaw remediation corrects them pre-deployment.

SI-4 System Monitoring
addresses: CWE-74

Identifies indicators of injection attacks (command, SQL, LDAP, etc.) via anomaly and attack monitoring.

References