Cyber Resilience

CVE-2023-1968

Illumina Nextseq 550Dx Firmware 1.0.0 – 1.3.1

Published
28 April 2023
Modified
21 November 2024
Patch / advisory
CVSS Score v3.1 10.0
Click a component to see what it means
Raw vectorCVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:C/C:H/I:H/A:H
EPSS Score 0.018 77th percentile
Risk Priority 77 floored blend · peak EPSS

Summary

CVE-2023-1968 is a critical-severity Binding to an Unrestricted IP Address (CWE-1327) vulnerability in Illumina Nextseq 550Dx Firmware. Its CVSS base score is 10.0 (Critical).

Operationally, exploitation aligns with the MITRE ATT&CK technique Exploit Public-Facing Application (T1190); ranked in the top 23% of CVEs by exploit likelihood; it is not currently listed in the CISA KEV catalog.

EU & UK References

Vulnerability Data

Instruments with Illumina Universal Copy Service v2.x are vulnerable due to binding to an unrestricted IP address. An unauthenticated malicious actor could use UCS to listen on all IP addresses, including those capable of accepting remote communications.

CWE(s)

Related Threats

MITRE ATT&CK Enterprise Techniques

T1190 Exploit Public-Facing Application Initial Access
Adversaries may attempt to exploit a weakness in an Internet-facing host or system to initially access a network.
T1210 Exploitation of Remote Services Lateral Movement
Adversaries may exploit remote services to gain unauthorized access to internal systems once inside of a network.
Derived from this CVE’s CWE(s) via the direct CWE→ATT&CK cross-walk.

CVEs Like This One

CVE-2023-1966Same product: Illumina Iscan
CVE-2024-49382Shared CWE-1327
CVE-2026-42503Shared CWE-1327
CVE-2024-36105Shared CWE-1327
CVE-2026-24015Shared CWE-1327
CVE-2025-61934Shared CWE-1327
CVE-2024-49383Shared CWE-1327
CVE-2025-55322Shared CWE-1327
CVE-2026-47873Shared CWE-1327
CVE-2025-11538Shared CWE-1327

Affected Assets

illumina
iscan firmware
4.0.0, 4.0.5
illumina
iseq 100 firmware
all versions
illumina
miniseq firmware
≥ 2.0
illumina
miseq firmware
≥ 4.0
illumina
miseqdx firmware
4.0 · ≥ 4.0.1
illumina
nextseq 500 firmware
4.0
illumina
nextseq 550 firmware
4.0
illumina
nextseq 550dx firmware
4.0 · 1.0.0 — 1.3.1 · ≥ 1.3.3
illumina
nextseq 1000 firmware
1.4.1
illumina
nextseq 2000 firmware
1.4.1
+1 more product configuration(s) — see NVD for full list

Mitigating Controls

Mitigating Controls (NIST CSF 2.0) AI

Derived directly from the weakness types (CWEs) cited in the NVD entry via our AI-authored CWE→CSF cross-walk (authority under review) — links open the control.

PR.PS-01 full match
prevents

Configuration management enforces restricted bind addresses, covering the weakness completely but only one aspect of overall hardening.

PR.IR-01 mostly match
prevents

Network protection controls directly prevent exposure via unrestricted binds while fixing the weakness addresses only one vector of unauthorized access.

ID.AM-03 partial match
prevents

Documenting authorized network flows informs correct bind decisions and reduces the chance of 0.0.0.0 usage.

Mitigating Controls (ISO/IEC 27001:2022 Annex A) AI

Derived directly from the weakness types (CWEs) cited in the NVD entry via our AI-authored CWE→ISO cross-walk (authority under review) — links open the control.

prevents

Security of network services includes hardening service bindings to prevent exposure on all interfaces.

prevents

Secure architecture principles discourage exposing services on all interfaces, though the control is broader than this single weakness.

mitigates

Network security controls directly require restricting listening interfaces to specific addresses rather than 0.0.0.0.

mitigates

Network segregation can limit the blast radius of an unrestricted binding but does not prevent the binding itself.

prevents

Secure coding guidance can catch hard-coded 0.0.0.0 bindings during development but is not the primary mitigation.

References