CVE-2025-12922
Published: 10 November 2025
Summary
CVE-2025-12922 is a low-severity Path Traversal (CWE-22) vulnerability in Openclinica Openclinica. Its CVSS base score is 2.1 (Low).
Operationally, exploitation aligns with the MITRE ATT&CK technique Exploit Public-Facing Application (T1190); ranked at the 26.4th percentile by exploit likelihood (below the median); it is not currently listed in the CISA KEV catalog.
The strongest mitigations our analysis identified are NIST 800-53 AC-3 (Access Enforcement) and SI-10 (Information Input Validation).
Deeper analysis
CVE-2025-12922 is a path traversal vulnerability (CWE-22) affecting OpenClinica Community Edition versions up to 3.12.2 and 3.13. The issue resides in an unknown part of the file /ImportCRFData?action=confirm within the CRF Data Import component, where manipulation of the xml_file argument enables attackers to traverse paths outside the intended directory. The vulnerability carries a CVSS v3.1 base score of 6.3 (AV:N/AC:L/PR:L/UI:N/S:U/C:L/I:L/A:L) and was published on 2025-11-10.
The vulnerability can be exploited remotely by low-privileged users (PR:L) over the network with low attack complexity and no user interaction required. Successful exploitation allows limited impacts on confidentiality, integrity, and availability, potentially enabling unauthorized file access, modification, or disruption via path traversal in the CRF data import functionality.
Advisories from VulDB and security researcher disclosures on GitHub detail the issue but note that the vendor was contacted early without any response, indicating no official patches or mitigations are available. Proof-of-concept exploits, including raw requests, have been publicly released.
In notable context, the exploit has been made public and could be used against unpatched instances, increasing the risk for deployments of the affected OpenClinica versions.
EU & UK References
- 🇪🇺 ENISA EUVD: EUVD-2025-38724
Vulnerability details
A vulnerability was found in OpenClinica Community Edition up to 3.12.2/3.13. This affects an unknown part of the file /ImportCRFData?action=confirm of the component CRF Data Import. Performing manipulation of the argument xml_file results in path traversal. The attack can be…
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initiated remotely. The exploit has been made public and could be used. The vendor was contacted early about this disclosure but did not respond in any way.
- CWE(s)
Related Threats
MITRE ATT&CK Enterprise TechniquesAI
Why these techniques?
Path traversal in public-facing OpenClinica web app (T1190: Exploit Public-Facing Application) enables arbitrary file reads from local system (T1005: Data from Local System).
CVEs Like This One
Affected Assets
Mitigating Controls
Mitigating Controls (NIST 800-53 r5) AI
Directly prevents path traversal exploitation by validating the xml_file argument in the CRF Data Import component to reject traversal sequences like '../'.
Enforces logical access controls at the file system level to block unauthorized reads, writes, or disruptions outside the intended import directory despite path manipulation.
Limits the impact of successful path traversal by ensuring the application and associated accounts operate with least privilege, restricting access to sensitive files.