Cyber Resilience

CVE-2026-31962

Memory Safety in Htslib ≤ 1.21.1

Published
18 March 2026
Modified
19 March 2026
Patch / advisory
CVSS Score v4 8.8
Click a component to see what it means
Raw vectorCVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:N/VC:L/VI:H/VA:L/SC:N/SI:N/SA:N/E:X/CR:X/IR:X/AR:X/MAV:X/MAC:X/MAT:X/MPR:X/MUI:X/MVC:X/MVI:X/MVA:X/MSC:X/MSI:X/MSA:X/S:X/AU:X/R:X/V:X/RE:X/U:X
EPSS Score 0.0036 29th percentile
Risk Priority 44 floored blend · peak EPSS

Summary

CVE-2026-31962 is a high-severity Heap-based Buffer Overflow (CWE-122) vulnerability in Htslib Htslib. Its CVSS base score is 8.8 (High).

Operationally, exploitation aligns with the MITRE ATT&CK technique Exploitation for Privilege Escalation (T1068); ranked at the 29th percentile by exploit likelihood (below the median); it is not currently listed in the CISA KEV catalog.

The strongest mitigations our analysis identified map to SA-11 (Developer Testing and Evaluation) and SI-10 (Information Input Validation) — see the control section below for these in your framework.

Deeper analysis AI-assisted summary

Synthesised by an AI model from the NVD description and linked references — a reading aid, not an authoritative source.

CVE-2026-31962 is a heap buffer overflow vulnerability in HTSlib, a C library for reading and writing bioinformatics file formats such as CRAM, which stores compressed DNA sequence alignment data. The issue arises in the `cram_decode_seq()` function, which fails to properly handle CRAM records that omit DNA sequence and quality values to save space. In affected cases, this leads to reading a single byte beyond the end of a heap allocation followed by writing an attacker-controlled byte to the same location, enabling heap structure corruption.

The vulnerability can be exploited by any remote attacker with no privileges required (PR:N) who tricks a user into opening a specially crafted CRAM file (UI:R), as indicated by the CVSS 3.1 score of 8.8 (AV:N/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H). Successful exploitation may cause the affected program to crash, overwrite arbitrary data or heap structures, and potentially achieve arbitrary code execution.

Patches are available in HTSlib versions 1.23.1, 1.22.2, and 1.21.1, as detailed in the project's GitHub security advisory (GHSA-xxmp-v7h3-gpwp) and the fixing commit (d799b54c6401879187bba4741be83ff590ac73e3). There is no workaround for this issue. The vulnerability is associated with CWEs-122 (Heap-based Buffer Overflow), CWE-125 (Out-of-bounds Read), CWE-129 (Improper Validation of Array Index), and CWE-787 (Out-of-bounds Write).

OWASP Top 10 for Web (2025)

EU & UK References

Vulnerability Data

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. While most alignment records store DNA sequence and quality values, the format also allows them to omit this…

more

data in certain cases to save space. Due to some quirks of the CRAM format, it is necessary to handle these records carefully as they will actually store data that needs to be consumed and then discarded. Unfortunately the `cram_decode_seq()` did not handle this correctly in some cases. Where this happened it could result in reading a single byte from beyond the end of a heap allocation, followed by writing a single attacker-controlled byte to the same location. Exploiting this bug causes a heap buffer overflow. If a user opens a file crafted to exploit this issue, it could lead to the program crashing, or overwriting of data and heap structures in ways not expected by the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

CWE(s)

Related Threats

MITRE ATT&CK Enterprise Techniques

T1068 Exploitation for Privilege Escalation Privilege Escalation
Adversaries may exploit software vulnerabilities in an attempt to elevate privileges.
T1190 Exploit Public-Facing Application Initial Access
Adversaries may attempt to exploit a weakness in an Internet-facing host or system to initially access a network.
T1203 Exploitation for Client Execution Execution
Adversaries may exploit software vulnerabilities in client applications to execute code.
T1210 Exploitation of Remote Services Lateral Movement
Adversaries may exploit remote services to gain unauthorized access to internal systems once inside of a network.
T1211 Exploitation for Stealth Stealth
Adversaries may exploit vulnerabilities to evade detection by hiding activity, suppressing logging, or operating within trusted or unmonitored components.
T1212 Exploitation for Credential Access Credential Access
Adversaries may exploit software vulnerabilities in an attempt to collect credentials.
Derived from this CVE’s CWE(s) via the direct CWE→ATT&CK cross-walk.

CVEs Like This One

CVE-2025-30376Shared CWE-122, CWE-125
CVE-2024-3758Shared CWE-122, CWE-787
CVE-2023-37294Shared CWE-122, CWE-787
CVE-2024-27374Shared CWE-122, CWE-787
CVE-2023-26416Shared CWE-122, CWE-787
CVE-2024-45139Shared CWE-122, CWE-787
CVE-2023-20081Shared CWE-122, CWE-787
CVE-2023-4692Shared CWE-122, CWE-787
CVE-2024-6816Shared CWE-122, CWE-787
CVE-2024-30288Shared CWE-122, CWE-787

Affected Assets

htslib
htslib
1.23 · ≤ 1.21.1 · 1.22 — 1.22.2

Mitigating Controls

Control response

Prevent
Stop it (NIST 800-53)

Detect
Catch it (NIST detect / respond)

Harden
Shrink the surface (DISA STIG)

Validate
Prove the fix (OWASP ASVS)
  • V1.4.1

Mitigating Controls (NIST 800-53 r5) AI

Developer testing and evaluation (including fuzzing and memory-error detectors) can discover heap overflows after they have been coded.

Input validation enforces bounds checking on data written to heap buffers, directly stopping the overflow condition from being introduced.

Requiring documented secure-development standards and tools can mandate bounds-checked coding practices that avoid the weakness.

Security engineering principles require use of memory-safe constructs and bounds-checked allocation routines that avoid introducing heap overflows.

Process isolation confines the effects of an out-of-bounds read to the compromised process.

Memory-protection mechanisms limit the ability of a heap overflow to execute attacker-controlled code or corrupt adjacent structures.

Mitigating Controls (NIST CSF 2.0) AI

Derived directly from the weakness types (CWEs) cited in the NVD entry via our AI-authored CWE→CSF cross-walk (authority under review) — links open the control.

PR.PS-06 full match
prevents

Secure-development practices directly require bounds checking and safe memory handling that prevent heap overflows.

ID.RA-01 partial match
prevents

Vulnerability scanning and recording can discover heap-overflow flaws but does not prevent their introduction in code.

PR.PS-02 partial match
prevents

Timely patching removes known heap-overflow instances after they exist.

Mitigating Controls (ISO/IEC 27001:2022 Annex A) AI

Derived directly from the weakness types (CWEs) cited in the NVD entry via our AI-authored CWE→ISO cross-walk (authority under review) — links open the control.

finds

Security testing in development and acceptance can detect heap overflows before release.

A.8.15 Logging partial match
finds

Logging can record evidence of an out-of-bounds read but does not prevent the weakness itself.

prevents

Secure development lifecycle mandates practices that reduce the likelihood of introducing heap overflows.

prevents

Application security requirements can specify bounds-checking and safe memory APIs that mitigate heap overflows.

prevents

Secure architecture and engineering principles include memory-safety and input-validation controls that address heap overflows.

prevents

Secure coding standards directly prescribe techniques (safe functions, bounds checks) that prevent heap-based buffer overflows.

References